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Blood Level Case Study
Efficacy of Oral Liposomal Glutathione
Supplementation in Increasing Blood Glutathione Levels and Improving
Symptoms Associated with Autism: An Observational Case Series
Leigh Ann Chapman ND, Will Gregory PhD, Heather
Zwickey PhD
ABSTRACT: Evidence suggests that autism spectrum
disorders are influenced by the intricate interface between
genetics, immune function, toxic environmental exposures, and
increased oxidative stress. Glutathione (GSH) serves as a potent
immune system activator and one of the human body's most powerful
antioxidants, providing cellular protection from the damage of free
radicals. This case series builds upon anecdotal evidence that oral
glutathione supplementation increases autistic patient's blood GSH
levels as well as improves clinical parameters in areas such as
communication, sociability, cognitive awareness and physical
symptoms. OBJECTIVE: To review cases of patients treated with oral
glutathione supplementation, Essential GSH®, during the course of
biomedical treatment of autism spectrum disorder and document
changes in blood GSH levels as well as symptoms of autism using the
Autism Treatment Evaluation Checklist (ATEC). METHODS:
Seven
children with a diagnosis of an Autism spectrum disorder are
assigned to receive daily supplementation with an oral liposomal
glutathione replacement in addition to customary biomedical
treatment. Whole blood glutathione was tested at baseline, three
weeks and six weeks of treatment. Behavioral, cognitive, social and
physical symptoms were monitored at the same intervals using the
Autism Treatment Evaluation Checklist (ATEC.) RESULTS:
The increase
of whole blood glutathione levels as well as improvement in behavior
and physical symptoms of children with autism was statistically
significant after oral liposomal glutathione, Essential GSH®,
replacement therapy.
METHODS:
Participants: The participants in this case study were seven
children with a diagnosis of autism. Participants were qualified if
baseline whole blood glutathione assay measured below 1000 micromol/L.
Sample Collection: Samples were taken after
three weeks and then again at six weeks after the initiation of
Essential GSH® supplementation.
Glutathione Replacement: Essential GSH® oral,
liposomal glutathione from Wellness Pharmacy® was dosed using 1/4
teaspoon (1.25 mL) for every 30 lbs of child's total bodyweight two
times per day. Typical dosage ranged from 200-400 mg total
glutathione per day.
Assessment: Symptoms of autism were tracked
using the Autism Treatment Evaluation Checklist (ATEC).
Results: Whole blood glutathione levels
increased significantly and change occurred in the severity of the
symptoms of autism as represented by the ATEC form. Increases in
whole blood glutathione were significantly associated with a
reduction in physical symptoms with other subscales trending toward
significance.
Figure 1: Means for ATEC Composite Scores Over Time
Figure 2: Average Glutathione Levels Over
Time
The actual means are: 840.4 (sd=157.6),
1049.6 (sd=186.9), 958.3 (sd=140.3)
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